5 packs: Save 3% = $ 128,04 per pack
10 packs: Save 5% = $ 125,40 per pack
20 packs: Save 8% = $ 121,44 per pack
30 packs: Save 10% = $ 118,80 per pack



Synvisc -One , 6 ml: glass syringe 10 ml (ACL 3401048640222 ) .

Hylan GF 20 is a viscoelastic fluid, sterile and non-pyrogenic containing Hylan. Hylands are hyaluronan derivatives ( sodium hyaluronate ), and they are composed of repeating disaccharide units of N- acetylglucosamine and sodium glucuronate.

The Hylan A has an average molecular weight of 6 million daltons, and the Hylan B gel is hydrated. Hylan GF 20 contains Hylan A and Hylan B ( 8.0 mg ± 2.0 mg / ml ) solution in physiological buffered saline ( pH 7.2 ± 0.3 ) .


To 1 mL ( 20 Hylan GF ) : hylan 8.0 mg , 8.5 mg sodium chloride , 0.16 mg disodium phosphate , sodium dihydrogen phosphate hydrate 0.04 mg Water for injection qs .

Synvisc contains 2 ml of Hylan G- F 20. Synvisc -One contains 6 ml of Hylan G- F 20.


Hylan G- 20 F :

is an agent of a temporary replacement and supplement of the synovial fluid ;

is effective when administered in all stages of joint disease ;

proves most effective when administered to patients with regular physical activity mobilizes the affected joint ;

Exerts its therapeutic effects by acting as viscosupplementation, restoring physiological and rheological properties of joint tissues affected by osteoarthritis.

Viscosupplementation with Hylan GF 20 is a treatment that reduces pain and discomfort, thereby increasing the joint’s range of motion. In vitro studies have shown that Hylan GF 20 protects cartilage cells against physical and chemical damage.

Instructions, Dosage

Synvisc should only be administered by intraarticular and a doctor to relieve pain associated with osteoarthritis of the knee, hip, ankle and shoulder.

Synvisc -One must only be administered intraarticular and a doctor to relieve pain associated with knee osteoarthritis.

Aspirate synovial fluid or effusion before each injection of Hylan GF 20.

Do not use Hylan GF 20 if the package is opened or damaged.

Inject at room temperature.

To remove the syringe from the blister shell ( or tray ), grasp the body without touching the piston rod.

The contents of the syringe should be used immediately after opening the package.

Unscrew the grey cap at the end of the syringe before removing it to minimize spilling.

Using an appropriate diameter needle :

Synvisc: syringe 18 to 22 gauge ;

Synvisc -One syringe 18 to 20 gauge.

According to the joint, use a middle of appropriate length to be treated.

To ensure a tight connection and prevent leakage during administration, fit securely in the needle clamp Luer syringe.

Do not tighten or apply excessive pressure to fix or remove the needle sheath under penalty of breaking the tip of the syringe.

Do not sterilize again Hylan G- F 20.

Inject only in the synovial space by operating, if necessary, under fluoroscopic guidance, particularly in the treatment of the hip joints and the shoulder.

The contents of the syringe are for single use only.

As the dosing recommendations indicate, inject the entire volume of the syringe.

When working under fluoroscopic control, a product of ionic or non-ionic contrast medium can be used.

Do not use more than 1 ml of contrast medium with 2 ml of Hylan GF 20.


The dosage of Hylan GF-20 depends on the joint to be treated.
Osteoarthritis of the knee:
Synvisc :

It is recommended to administer Synvisc in a regimen of three injections, one week apart each. For optimal effect, it is essential to administer three injections. The maximum recommended dose is 6 injections over six months, providing at least 4 weeks between treatment cycles.
Synvisc- One:

It is recommended to administer Synvisc -One in a regimen of one injection in the knee. A second injection can be given 6 months after the first if the patient’s symptoms warrant it.
Osteoarthritis of the hip, ankle and shoulder :
Synvisc :

It is recommended to administer an initial Synvisc one injection regimen. If, however, adequate symptomatic relief is not obtained after the injection, it is recommended to issue a second injection. Clinical data have shown that patients feel better from this second injection when administered between 1 and 3 months after the first injection.
Duration of effects :

Treatment with Hylan GF 20 affects only the treated joint; it causes no systemic effect.
Synvisc :

For patients who respond favourably to treatment, the duration of the therapeutic effect is usually up to 26 weeks, although holdovers longer or shorter were observed. However, prospective clinical data showed that patients with osteoarthritis of the knee had responded favourably to treatment up to 52 weeks after a single series of three injections of Synvisc.
Synvisc- One:

Prospective clinical data show an effect of treatment up to 26 weeks after a single injection of Synvisc- One.

Cons -indications

In venous or lymphatic stasis in the corresponding member, it should not inject Hylan GF 20 in the joint.

Should not inject Hylan GF 20 in an infected joint or severely inflamed or in patients with skin disease or infection at the injection site.

Do not freeze.

Do not use it if the package is opened or damaged.



Synvisc is an osteoarthritis pain relief treatment intended for the treatment of especially the knee, but also hips, ankles and shoulders. The products are indicated for the treatment of pain caused by osteoarthritis. Synvisc (hylan G-F 20) is a high molecular weight fluid similar to the fluid that surrounds the joints in our bodies. When injected, the fluid acts as a lubricant and shock absorber for the joints.


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